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Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis

BACKGROUND: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life....

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Autores principales: Julia, Nentwich, Katharina, Ruf, Hermann, Girschick, Annette, Holl-Wieden, Henner, Morbach, Helge, Hebestreit, Christine, Hofmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639948/
https://www.ncbi.nlm.nih.gov/pubmed/31319856
http://dx.doi.org/10.1186/s12969-019-0351-4
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author Julia, Nentwich
Katharina, Ruf
Hermann, Girschick
Annette, Holl-Wieden
Henner, Morbach
Helge, Hebestreit
Christine, Hofmann
author_facet Julia, Nentwich
Katharina, Ruf
Hermann, Girschick
Annette, Holl-Wieden
Henner, Morbach
Helge, Hebestreit
Christine, Hofmann
author_sort Julia, Nentwich
collection PubMed
description BACKGROUND: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physical activity, fitness and health-related quality of life (HRQOL) in adolescents with established diagnosis of CNO versus healthy controls (HC). METHODS: 15 patients with CNO and 15 age and gender matched HC aged 13–18 years, completed questionnaires, performed an incremental exercise test with gas exchange measures up to voluntary fatigue and wore an accelerometer over 7 days at home to assess physical activity behavior. RESULTS: At the time of assessment, 5 CNO patients were in clinical, one in radiological and 5 in clinical and radiological remission. 7 did not receive any therapy at the time of assessment. The results of the exercise test and of the accelerometry did not show any significant difference between CNO and HC. However, reported sports participation was lower in patients with CNO and PedsQL3.0 and 4.0 showed significant lower values in most of the scores indicating reduced HRQOL. CONCLUSION: Although most CNO patients showed a favorable course of disease without any relevant differences in objective measurements of physical activity and fitness versus HC at the time of assessment, questionnaires revealed perceived limitations. Further studies are needed to measure HRQOL and to validate questionnaires in patients with CNO against objective measures including more participants with a higher level of disease activity.
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spelling pubmed-66399482019-07-29 Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis Julia, Nentwich Katharina, Ruf Hermann, Girschick Annette, Holl-Wieden Henner, Morbach Helge, Hebestreit Christine, Hofmann Pediatr Rheumatol Online J Research Article BACKGROUND: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physical activity, fitness and health-related quality of life (HRQOL) in adolescents with established diagnosis of CNO versus healthy controls (HC). METHODS: 15 patients with CNO and 15 age and gender matched HC aged 13–18 years, completed questionnaires, performed an incremental exercise test with gas exchange measures up to voluntary fatigue and wore an accelerometer over 7 days at home to assess physical activity behavior. RESULTS: At the time of assessment, 5 CNO patients were in clinical, one in radiological and 5 in clinical and radiological remission. 7 did not receive any therapy at the time of assessment. The results of the exercise test and of the accelerometry did not show any significant difference between CNO and HC. However, reported sports participation was lower in patients with CNO and PedsQL3.0 and 4.0 showed significant lower values in most of the scores indicating reduced HRQOL. CONCLUSION: Although most CNO patients showed a favorable course of disease without any relevant differences in objective measurements of physical activity and fitness versus HC at the time of assessment, questionnaires revealed perceived limitations. Further studies are needed to measure HRQOL and to validate questionnaires in patients with CNO against objective measures including more participants with a higher level of disease activity. BioMed Central 2019-07-18 /pmc/articles/PMC6639948/ /pubmed/31319856 http://dx.doi.org/10.1186/s12969-019-0351-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Julia, Nentwich
Katharina, Ruf
Hermann, Girschick
Annette, Holl-Wieden
Henner, Morbach
Helge, Hebestreit
Christine, Hofmann
Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title_full Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title_fullStr Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title_full_unstemmed Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title_short Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
title_sort physical activity and health-related quality of life in chronic non-bacterial osteomyelitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639948/
https://www.ncbi.nlm.nih.gov/pubmed/31319856
http://dx.doi.org/10.1186/s12969-019-0351-4
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