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Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

BACKGROUND: Sorafenib is the first-line treatment for advanced-stage hepatocellular carcinoma (HCC). Several studies have shown that the up-regulation of β-catenin plays a role in sorafenib resistance in HCC; however, the mechanism associated with this phenomenon remains elusive. METHODS: Western bl...

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Detalles Bibliográficos
Autores principales:	Deng, Ling, Sun, Jingyuan, Chen, Xiaohui, Liu, Li, Wu, Dehua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639974/ https://www.ncbi.nlm.nih.gov/pubmed/31319849 http://dx.doi.org/10.1186/s13046-019-1311-z

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