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Targeting WDR5: A WINning Anti-Cancer Strategy?

WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known as the WDR5-interaction (WIN) site, have been proposed to selectively kill M...

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Detalles Bibliográficos
Autores principales:	Aho, Erin R, Weissmiller, April M, Fesik, Stephen W, Tansey, William P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640055/ https://www.ncbi.nlm.nih.gov/pubmed/31360909 http://dx.doi.org/10.1177/2516865719865282

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