Oral Delivery of the P2Y(12) Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4(−/−) Mouse Model of Retinal Degeneration

PURPOSE: Accumulation of lysosomal waste is linked to neurodegeneration in multiple diseases, and pharmacologic enhancement of lysosomal activity is hypothesized to reduce pathology. An excessive accumulation of lysosomal-associated lipofuscin waste and an elevated lysosomal pH occur in retinal pigm...

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Detalles Bibliográficos
Autores principales: Lu, Wennan, Campagno, Keith E., Tso, Huen-Yee, Cenaj, Aurora, Laties, Alan M., Carlsson, Leif G., Mitchell, Claire H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640265/
https://www.ncbi.nlm.nih.gov/pubmed/31319418
http://dx.doi.org/10.1167/iovs.19-27241

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