Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability

The mammalian sirtuin, SIRT6, is a key tumor suppressor that maintains genome stability and regulates transcription, though how SIRT6 family members control genome stability is unclear. Here, we use multiple genome-wide approaches to demonstrate that the yeast SIRT6 homologs, Hst3 and Hst4, prevent...

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Detalles Bibliográficos
Autores principales: Feldman, Jessica L., Peterson, Craig L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640630/
https://www.ncbi.nlm.nih.gov/pubmed/31167142
http://dx.doi.org/10.1016/j.celrep.2019.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640630/
https://www.ncbi.nlm.nih.gov/pubmed/31167142
http://dx.doi.org/10.1016/j.celrep.2019.05.009

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