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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability
The mammalian sirtuin, SIRT6, is a key tumor suppressor that maintains genome stability and regulates transcription, though how SIRT6 family members control genome stability is unclear. Here, we use multiple genome-wide approaches to demonstrate that the yeast SIRT6 homologs, Hst3 and Hst4, prevent...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640630/ https://www.ncbi.nlm.nih.gov/pubmed/31167142 http://dx.doi.org/10.1016/j.celrep.2019.05.009 |