Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2

Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles. To enable exposure-safety and exposure-efficacy analyses, as well as to understand the metabolism of ADC therapeutics, three b...

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Detalles Bibliográficos
Autores principales: Faria, Morse, Peay, Marlking, Lam, Brandon, Ma, Eric, Yuan, Moucun, Waldron, Michael, Mylott, William R., Liang, Meina, Rosenbaum, Anton I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640689/
https://www.ncbi.nlm.nih.gov/pubmed/31544817
http://dx.doi.org/10.3390/antib8010011

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