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Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries

To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (scFv) display libraries in yeast. Such methods typ...

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Detalles Bibliográficos
Autores principales:	Medina-Cucurella, Angélica V., Mizrahi, Rena A., Asensio, Michael A., Edgar, Robert C., Leong, Jackson, Leong, Renee, Lim, Yoong Wearn, Nelson, Ayla, Niedecken, Ariel R., Simons, Jan Fredrik, Spindler, Matthew J., Stadtmiller, Kacy, Wayham, Nicholas, Adler, Adam S., Johnson, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640694/ https://www.ncbi.nlm.nih.gov/pubmed/31544823 http://dx.doi.org/10.3390/antib8010017

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