Cargando…
Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (scFv) display libraries in yeast. Such methods typ...
Autores principales: | Medina-Cucurella, Angélica V., Mizrahi, Rena A., Asensio, Michael A., Edgar, Robert C., Leong, Jackson, Leong, Renee, Lim, Yoong Wearn, Nelson, Ayla, Niedecken, Ariel R., Simons, Jan Fredrik, Spindler, Matthew J., Stadtmiller, Kacy, Wayham, Nicholas, Adler, Adam S., Johnson, David S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640694/ https://www.ncbi.nlm.nih.gov/pubmed/31544823 http://dx.doi.org/10.3390/antib8010017 |
Ejemplares similares
-
Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics
por: Asensio, Michael A., et al.
Publicado: (2019) -
GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2
por: Mizrahi, Rena A., et al.
Publicado: (2022) -
A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern
por: Wayham, Nicholas P, et al.
Publicado: (2023) -
Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
por: Simons, Jan Fredrik, et al.
Publicado: (2020) -
Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics
por: Adler, Adam S., et al.
Publicado: (2017)