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Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities

RHO (Ras HOmologous) GTPases are molecular switches that activate, in their state bound to Guanosine triphosphate (GTP), key signaling pathways, which involve actin cytoskeleton dynamics. Previously, we selected the nanobody RH12, from a synthetic phage display library, which binds the GTP-bound act...

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Detalles Bibliográficos
Autores principales:	Keller, Laura, Bery, Nicolas, Tardy, Claudine, Ligat, Laetitia, Favre, Gilles, Rabbitts, Terence H., Olichon, Aurélien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640709/ https://www.ncbi.nlm.nih.gov/pubmed/31544814 http://dx.doi.org/10.3390/antib8010008

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