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Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation
The biological activity of therapeutic antibodies is highly influenced by their glycosylation profile. A valuable method for increasing the cytotoxic efficacy of antibodies, which are used, for example, in cancer treatment, is the reduction of core fucosylation, as this enhances the elimination of t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640710/ https://www.ncbi.nlm.nih.gov/pubmed/31544815 http://dx.doi.org/10.3390/antib8010009 |