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Phenolic Activation in Chiral Brønsted Acid-Catalyzed Intramolecular α-Amidoalkylation Reactions for the Synthesis of Fused Isoquinolines

[Image: see text] An organolithium addition–intramolecular α-amidoalkylation sequence on N-phenethylimides has been developed for the synthesis of fused tetrahydroisoquinoline systems using 1,1′-bi-2-naphthol (binol)-derived Brønsted acids. This transformation is the first in which activated benzene...

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Detalles Bibliográficos
Autores principales:	Aranzamendi, Eider, Sotomayor, Nuria, Lete, Esther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641169/ https://www.ncbi.nlm.nih.gov/pubmed/31457610 http://dx.doi.org/10.1021/acsomega.7b00170

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