Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents

[Image: see text] Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challeng...

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Detalles Bibliográficos
Autores principales: Hane, Francis T., Fernando, Ashvin, Prete, Braedan R. J., Peloquin, Brianna, Karas, Scott, Chaudhuri, Sauradip, Chahal, Simrun, Shepelytskyi, Yurii, Wade, Alanna, Li, Tao, DeBoef, Brenton, Albert, Mitchell S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641221/
https://www.ncbi.nlm.nih.gov/pubmed/31457922
http://dx.doi.org/10.1021/acsomega.7b01744
Descripción
Sumario:[Image: see text] Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced (129)Xe MR spectroscopy.

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