Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents

[Image: see text] Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challeng...

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Autores principales: Hane, Francis T., Fernando, Ashvin, Prete, Braedan R. J., Peloquin, Brianna, Karas, Scott, Chaudhuri, Sauradip, Chahal, Simrun, Shepelytskyi, Yurii, Wade, Alanna, Li, Tao, DeBoef, Brenton, Albert, Mitchell S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641221/
https://www.ncbi.nlm.nih.gov/pubmed/31457922
http://dx.doi.org/10.1021/acsomega.7b01744
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author Hane, Francis T.
Fernando, Ashvin
Prete, Braedan R. J.
Peloquin, Brianna
Karas, Scott
Chaudhuri, Sauradip
Chahal, Simrun
Shepelytskyi, Yurii
Wade, Alanna
Li, Tao
DeBoef, Brenton
Albert, Mitchell S.
author_facet Hane, Francis T.
Fernando, Ashvin
Prete, Braedan R. J.
Peloquin, Brianna
Karas, Scott
Chaudhuri, Sauradip
Chahal, Simrun
Shepelytskyi, Yurii
Wade, Alanna
Li, Tao
DeBoef, Brenton
Albert, Mitchell S.
author_sort Hane, Francis T.
collection PubMed
description [Image: see text] Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced (129)Xe MR spectroscopy.
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spelling pubmed-66412212019-08-27 Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents Hane, Francis T. Fernando, Ashvin Prete, Braedan R. J. Peloquin, Brianna Karas, Scott Chaudhuri, Sauradip Chahal, Simrun Shepelytskyi, Yurii Wade, Alanna Li, Tao DeBoef, Brenton Albert, Mitchell S. ACS Omega [Image: see text] Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced (129)Xe MR spectroscopy. American Chemical Society 2018-01-19 /pmc/articles/PMC6641221/ /pubmed/31457922 http://dx.doi.org/10.1021/acsomega.7b01744 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Hane, Francis T.
Fernando, Ashvin
Prete, Braedan R. J.
Peloquin, Brianna
Karas, Scott
Chaudhuri, Sauradip
Chahal, Simrun
Shepelytskyi, Yurii
Wade, Alanna
Li, Tao
DeBoef, Brenton
Albert, Mitchell S.
Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title_full Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title_fullStr Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title_full_unstemmed Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title_short Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
title_sort cyclodextrin-based pseudorotaxanes: easily conjugatable scaffolds for synthesizing hyperpolarized xenon-129 magnetic resonance imaging agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641221/
https://www.ncbi.nlm.nih.gov/pubmed/31457922
http://dx.doi.org/10.1021/acsomega.7b01744
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