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Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones
[Image: see text] An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of para-quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol pr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641250/ https://www.ncbi.nlm.nih.gov/pubmed/31458470 http://dx.doi.org/10.1021/acsomega.7b01745 |
| _version_ | 1783436737603698688 |
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| author | Liu, Teng Liu, Jianjun Xia, Shubiao Meng, Jie Shen, Xianfu Zhu, Xiufang Chen, Wenchang Sun, Chengke Cheng, Feixiang |
| author_facet | Liu, Teng Liu, Jianjun Xia, Shubiao Meng, Jie Shen, Xianfu Zhu, Xiufang Chen, Wenchang Sun, Chengke Cheng, Feixiang |
| author_sort | Liu, Teng |
| collection | PubMed |
| description | [Image: see text] An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of para-quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol provided a highly chemo- and regioselectivity synthesis of a diverse array of novel diarylmethyl sulfones with excellent yields, and the reaction could be scaled up. |
| format | Online Article Text |
| id | pubmed-6641250 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-66412502019-08-27 Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones Liu, Teng Liu, Jianjun Xia, Shubiao Meng, Jie Shen, Xianfu Zhu, Xiufang Chen, Wenchang Sun, Chengke Cheng, Feixiang ACS Omega [Image: see text] An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of para-quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol provided a highly chemo- and regioselectivity synthesis of a diverse array of novel diarylmethyl sulfones with excellent yields, and the reaction could be scaled up. American Chemical Society 2018-02-02 /pmc/articles/PMC6641250/ /pubmed/31458470 http://dx.doi.org/10.1021/acsomega.7b01745 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Liu, Teng Liu, Jianjun Xia, Shubiao Meng, Jie Shen, Xianfu Zhu, Xiufang Chen, Wenchang Sun, Chengke Cheng, Feixiang Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones |
| title | Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation
of para-Quinone Methides: Facile Access to Diarylmethyl
Sulfones |
| title_full | Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation
of para-Quinone Methides: Facile Access to Diarylmethyl
Sulfones |
| title_fullStr | Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation
of para-Quinone Methides: Facile Access to Diarylmethyl
Sulfones |
| title_full_unstemmed | Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation
of para-Quinone Methides: Facile Access to Diarylmethyl
Sulfones |
| title_short | Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation
of para-Quinone Methides: Facile Access to Diarylmethyl
Sulfones |
| title_sort | catalyst-free 1,6-conjugate addition/aromatization/sulfonylation
of para-quinone methides: facile access to diarylmethyl
sulfones |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641250/ https://www.ncbi.nlm.nih.gov/pubmed/31458470 http://dx.doi.org/10.1021/acsomega.7b01745 |
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