Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones

[Image: see text] A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C–C bond via intramolecular Friedel–Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Sign...

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Autores principales: Niharika, Pedireddi, Ramulu, Bokka Venkat, Satyanarayana, Gedu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641420/
https://www.ncbi.nlm.nih.gov/pubmed/31457889
http://dx.doi.org/10.1021/acsomega.7b01553
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author Niharika, Pedireddi
Ramulu, Bokka Venkat
Satyanarayana, Gedu
author_facet Niharika, Pedireddi
Ramulu, Bokka Venkat
Satyanarayana, Gedu
author_sort Niharika, Pedireddi
collection PubMed
description [Image: see text] A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C–C bond via intramolecular Friedel–Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Significantly, these fused tricyclic compounds are ubiquitous and constitute major structural cores of natural products.
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spelling pubmed-66414202019-08-27 Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones Niharika, Pedireddi Ramulu, Bokka Venkat Satyanarayana, Gedu ACS Omega [Image: see text] A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C–C bond via intramolecular Friedel–Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Significantly, these fused tricyclic compounds are ubiquitous and constitute major structural cores of natural products. American Chemical Society 2018-01-09 /pmc/articles/PMC6641420/ /pubmed/31457889 http://dx.doi.org/10.1021/acsomega.7b01553 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Niharika, Pedireddi
Ramulu, Bokka Venkat
Satyanarayana, Gedu
Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title_full Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title_fullStr Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title_full_unstemmed Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title_short Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones
title_sort brønsted acid-mediated domino one-pot dual c–c bond formation: chemoselective synthesis of fused tricyclic ketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641420/
https://www.ncbi.nlm.nih.gov/pubmed/31457889
http://dx.doi.org/10.1021/acsomega.7b01553
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AT satyanarayanagedu brønstedacidmediateddominoonepotdualccbondformationchemoselectivesynthesisoffusedtricyclicketones

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