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Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China

Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), an active surveillance program has been conducted from 2013 to 2015 in Guangdong, China. The...

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Autores principales: Cao, Zhenpeng, Zeng, Weijie, Hao, Xiangqi, Huang, Junming, Cai, Mengkai, Zhou, Pei, Zhang, Guihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641472/
https://www.ncbi.nlm.nih.gov/pubmed/31323023
http://dx.doi.org/10.1371/journal.pone.0217607
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author Cao, Zhenpeng
Zeng, Weijie
Hao, Xiangqi
Huang, Junming
Cai, Mengkai
Zhou, Pei
Zhang, Guihong
author_facet Cao, Zhenpeng
Zeng, Weijie
Hao, Xiangqi
Huang, Junming
Cai, Mengkai
Zhou, Pei
Zhang, Guihong
author_sort Cao, Zhenpeng
collection PubMed
description Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), an active surveillance program has been conducted from 2013 to 2015 in Guangdong, China. The phylogenetic analyses showed that the external genes of the isolates were assigned to the Eurasian avian-like swine (EA) H1N1 and/or human-like H3N2 lineages with multiple substitutions, indicating a notable genetic shift. Moreover, the internal genes derived from different origins (PB2, PB1, PA, NP: pdm/09 (pandemic influenza virus 2009)-origin, M: pdm/09- or EA-origin, NS: North American Triple Reassortant (TR)-origin have become the dominant backbone of IAV-S in southern China. According to the origins of the eight gene segments, the isolates can be categorized into five genotypes. The results of mice experiment showed that the YJ4 (genotype 1) and DG2 (genotype 4) are the most pathogenic to mice, and the viruses are observed in kidneys and brains, indicating the systemic infection. The alterations of the IAV-S gene composition supported the continued implementation of the intensive surveillance of IAV-S and the greater attention focused on potential shifts toward transmission to humans.
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spelling pubmed-66414722019-07-25 Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China Cao, Zhenpeng Zeng, Weijie Hao, Xiangqi Huang, Junming Cai, Mengkai Zhou, Pei Zhang, Guihong PLoS One Research Article Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), an active surveillance program has been conducted from 2013 to 2015 in Guangdong, China. The phylogenetic analyses showed that the external genes of the isolates were assigned to the Eurasian avian-like swine (EA) H1N1 and/or human-like H3N2 lineages with multiple substitutions, indicating a notable genetic shift. Moreover, the internal genes derived from different origins (PB2, PB1, PA, NP: pdm/09 (pandemic influenza virus 2009)-origin, M: pdm/09- or EA-origin, NS: North American Triple Reassortant (TR)-origin have become the dominant backbone of IAV-S in southern China. According to the origins of the eight gene segments, the isolates can be categorized into five genotypes. The results of mice experiment showed that the YJ4 (genotype 1) and DG2 (genotype 4) are the most pathogenic to mice, and the viruses are observed in kidneys and brains, indicating the systemic infection. The alterations of the IAV-S gene composition supported the continued implementation of the intensive surveillance of IAV-S and the greater attention focused on potential shifts toward transmission to humans. Public Library of Science 2019-07-19 /pmc/articles/PMC6641472/ /pubmed/31323023 http://dx.doi.org/10.1371/journal.pone.0217607 Text en © 2019 Cao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cao, Zhenpeng
Zeng, Weijie
Hao, Xiangqi
Huang, Junming
Cai, Mengkai
Zhou, Pei
Zhang, Guihong
Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title_full Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title_fullStr Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title_full_unstemmed Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title_short Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China
title_sort continuous evolution of influenza a viruses of swine from 2013 to 2015 in guangdong, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641472/
https://www.ncbi.nlm.nih.gov/pubmed/31323023
http://dx.doi.org/10.1371/journal.pone.0217607
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