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Pyrene-Terminated, Amphiphilic Polypeptide and Its Hydrogen-Bonded Interpolymer Complex as Delivery Systems of Doxorubicin
[Image: see text] The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I(1)/I(3), as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and it...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641489/ https://www.ncbi.nlm.nih.gov/pubmed/31458669 http://dx.doi.org/10.1021/acsomega.8b00124 |
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author | Tsai, Chun-Yi Chung, Chin-Hsiang Hong, Jin-Long |
author_facet | Tsai, Chun-Yi Chung, Chin-Hsiang Hong, Jin-Long |
author_sort | Tsai, Chun-Yi |
collection | PubMed |
description | [Image: see text] The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I(1)/I(3), as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA). Primarily, an amphiphilic PPM with a hydrophobic Py terminal and hydrophilic methoxy-bis(ethylene oxide) pendant groups was synthesized through multiple preparative steps, and the resultant PPM was thoroughly mixed with PAA through a preferable hydrogen bond (H bond) interaction to form HIPC. The emission study suggested that the I(1)/I(3) ratio and the quantum yield (Φ(F)) are effective in determining the critical concentrations of the aqueous PPM and PPM/PAA solutions. Moreover, the I(1)/I(3) ratio and Φ(F) were found to be convenient measures for determining the amounts of doxorubicin drugs loaded by and released from the aqueous PPM and PPM/PAA solutions. |
format | Online Article Text |
id | pubmed-6641489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-66414892019-08-27 Pyrene-Terminated, Amphiphilic Polypeptide and Its Hydrogen-Bonded Interpolymer Complex as Delivery Systems of Doxorubicin Tsai, Chun-Yi Chung, Chin-Hsiang Hong, Jin-Long ACS Omega [Image: see text] The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I(1)/I(3), as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA). Primarily, an amphiphilic PPM with a hydrophobic Py terminal and hydrophilic methoxy-bis(ethylene oxide) pendant groups was synthesized through multiple preparative steps, and the resultant PPM was thoroughly mixed with PAA through a preferable hydrogen bond (H bond) interaction to form HIPC. The emission study suggested that the I(1)/I(3) ratio and the quantum yield (Φ(F)) are effective in determining the critical concentrations of the aqueous PPM and PPM/PAA solutions. Moreover, the I(1)/I(3) ratio and Φ(F) were found to be convenient measures for determining the amounts of doxorubicin drugs loaded by and released from the aqueous PPM and PPM/PAA solutions. American Chemical Society 2018-04-24 /pmc/articles/PMC6641489/ /pubmed/31458669 http://dx.doi.org/10.1021/acsomega.8b00124 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Tsai, Chun-Yi Chung, Chin-Hsiang Hong, Jin-Long Pyrene-Terminated, Amphiphilic Polypeptide and Its Hydrogen-Bonded Interpolymer Complex as Delivery Systems of Doxorubicin |
title | Pyrene-Terminated, Amphiphilic
Polypeptide and Its Hydrogen-Bonded
Interpolymer Complex as Delivery Systems of Doxorubicin |
title_full | Pyrene-Terminated, Amphiphilic
Polypeptide and Its Hydrogen-Bonded
Interpolymer Complex as Delivery Systems of Doxorubicin |
title_fullStr | Pyrene-Terminated, Amphiphilic
Polypeptide and Its Hydrogen-Bonded
Interpolymer Complex as Delivery Systems of Doxorubicin |
title_full_unstemmed | Pyrene-Terminated, Amphiphilic
Polypeptide and Its Hydrogen-Bonded
Interpolymer Complex as Delivery Systems of Doxorubicin |
title_short | Pyrene-Terminated, Amphiphilic
Polypeptide and Its Hydrogen-Bonded
Interpolymer Complex as Delivery Systems of Doxorubicin |
title_sort | pyrene-terminated, amphiphilic
polypeptide and its hydrogen-bonded
interpolymer complex as delivery systems of doxorubicin |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641489/ https://www.ncbi.nlm.nih.gov/pubmed/31458669 http://dx.doi.org/10.1021/acsomega.8b00124 |
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