Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol

[Image: see text] The four-step procedure involving bromination, reduction, and nucleophilic substitution via elimination/addition previously applied to 1-(2-pyridyl)-2-propen-1-ol for the synthesis of indolizidine systems has now been extended to 1-(2-quinolyl)-2-propen-1-ol allowing a general acce...

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Autores principales: Giomi, Donatella, Ceccarelli, Jacopo, Brandi, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641500/
https://www.ncbi.nlm.nih.gov/pubmed/31458576
http://dx.doi.org/10.1021/acsomega.8b00167
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author Giomi, Donatella
Ceccarelli, Jacopo
Brandi, Alberto
author_facet Giomi, Donatella
Ceccarelli, Jacopo
Brandi, Alberto
author_sort Giomi, Donatella
collection PubMed
description [Image: see text] The four-step procedure involving bromination, reduction, and nucleophilic substitution via elimination/addition previously applied to 1-(2-pyridyl)-2-propen-1-ol for the synthesis of indolizidine systems has now been extended to 1-(2-quinolyl)-2-propen-1-ol allowing a general access to benzo-fused derivatives. For instance, (±)-benzo[e]lentiginosine has been easily synthesized in an 18% overall yield.
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spelling pubmed-66415002019-08-27 Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol Giomi, Donatella Ceccarelli, Jacopo Brandi, Alberto ACS Omega [Image: see text] The four-step procedure involving bromination, reduction, and nucleophilic substitution via elimination/addition previously applied to 1-(2-pyridyl)-2-propen-1-ol for the synthesis of indolizidine systems has now been extended to 1-(2-quinolyl)-2-propen-1-ol allowing a general access to benzo-fused derivatives. For instance, (±)-benzo[e]lentiginosine has been easily synthesized in an 18% overall yield. American Chemical Society 2018-03-15 /pmc/articles/PMC6641500/ /pubmed/31458576 http://dx.doi.org/10.1021/acsomega.8b00167 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Giomi, Donatella
Ceccarelli, Jacopo
Brandi, Alberto
Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title_full Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title_fullStr Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title_full_unstemmed Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title_short Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
title_sort synthesis of new indolizidine derivatives from 1-(2-quinolyl)-2-propen-1-ol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641500/
https://www.ncbi.nlm.nih.gov/pubmed/31458576
http://dx.doi.org/10.1021/acsomega.8b00167
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