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Holistic Prediction of Enantioselectivity in Asymmetric Catalysis
When faced with unfamiliar reaction space, synthetic chemists typically apply reported conditions (reagents, catalyst, solvent, additives) from closely-related reactions to new substrate types. Unfortunately, this approach often fails due to subtle, albeit important, differences in reaction requirem...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641578/ https://www.ncbi.nlm.nih.gov/pubmed/31316193 http://dx.doi.org/10.1038/s41586-019-1384-z |