Solvent-Free Chemoselective Hydrogenation of Squalene to Squalane

[Image: see text] Squalene is selectively and entirely converted into squalane over the spherical sol–gel-entrapped Pd catalyst SiliaCat Pd(0) under solvent-free and mild reaction conditions of 3 bar H(2) and 70 °C. The catalyst was reused successfully in eight consecutive cycles, with palladium leaching values <2 ppm, opening the route to sustainable and less-expensive hydrogenation of phytosqualene with important sustainability consequences.