Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones

[Image: see text] A general and efficient visible-light-induced CF(2) radical-based cascade reaction of o-hydroxyaryl enaminones has been described. This protocol afforded the corresponding functionalized 3-CF(2)-containing chromones in generally good yields under mild reaction conditions. The use o...

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Autores principales: Gao, Huang, Hu, Bei, Dong, Wuheng, Gao, Xiaoshuang, Jiang, Lili, Xie, Xiaomin, Zhang, Zhaoguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641644/
https://www.ncbi.nlm.nih.gov/pubmed/31457645
http://dx.doi.org/10.1021/acsomega.7b00383
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author Gao, Huang
Hu, Bei
Dong, Wuheng
Gao, Xiaoshuang
Jiang, Lili
Xie, Xiaomin
Zhang, Zhaoguo
author_facet Gao, Huang
Hu, Bei
Dong, Wuheng
Gao, Xiaoshuang
Jiang, Lili
Xie, Xiaomin
Zhang, Zhaoguo
author_sort Gao, Huang
collection PubMed
description [Image: see text] A general and efficient visible-light-induced CF(2) radical-based cascade reaction of o-hydroxyaryl enaminones has been described. This protocol afforded the corresponding functionalized 3-CF(2)-containing chromones in generally good yields under mild reaction conditions. The use of NaHSO(3), which has both basicity and reducibility, efficiently suppressed the formation of two byproducts, 4H-chromen-4-one and 3-bromo-4H-chromen-4-one.
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spelling pubmed-66416442019-08-27 Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones Gao, Huang Hu, Bei Dong, Wuheng Gao, Xiaoshuang Jiang, Lili Xie, Xiaomin Zhang, Zhaoguo ACS Omega [Image: see text] A general and efficient visible-light-induced CF(2) radical-based cascade reaction of o-hydroxyaryl enaminones has been described. This protocol afforded the corresponding functionalized 3-CF(2)-containing chromones in generally good yields under mild reaction conditions. The use of NaHSO(3), which has both basicity and reducibility, efficiently suppressed the formation of two byproducts, 4H-chromen-4-one and 3-bromo-4H-chromen-4-one. American Chemical Society 2017-07-05 /pmc/articles/PMC6641644/ /pubmed/31457645 http://dx.doi.org/10.1021/acsomega.7b00383 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Gao, Huang
Hu, Bei
Dong, Wuheng
Gao, Xiaoshuang
Jiang, Lili
Xie, Xiaomin
Zhang, Zhaoguo
Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title_full Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title_fullStr Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title_full_unstemmed Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title_short Synthesis of 3-CF(2)-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones
title_sort synthesis of 3-cf(2)-containing chromones via a visible-light-induced radical cascade reaction of o-hydroxyaryl enaminones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641644/
https://www.ncbi.nlm.nih.gov/pubmed/31457645
http://dx.doi.org/10.1021/acsomega.7b00383
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