C–H Imidation of 7-Deazapurines

[Image: see text] We developed and presented here a ferrocene-catalyzed C–H imidation of 7-deazapurines (pyrrolo[2,3-d]pyrimidines) with N-imidyl peroxyesters. The reactions occur regioselectively at position 8 in 7-deazapurines, leading to a series of 8-succinimido-, phtalimido-, or naphthalimido-7...

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Autores principales: Sabat, Nazarii, Poštová Slavětínská, Lenka, Klepetářová, Blanka, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641682/
https://www.ncbi.nlm.nih.gov/pubmed/31458688
http://dx.doi.org/10.1021/acsomega.8b00520
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author Sabat, Nazarii
Poštová Slavětínská, Lenka
Klepetářová, Blanka
Hocek, Michal
author_facet Sabat, Nazarii
Poštová Slavětínská, Lenka
Klepetářová, Blanka
Hocek, Michal
author_sort Sabat, Nazarii
collection PubMed
description [Image: see text] We developed and presented here a ferrocene-catalyzed C–H imidation of 7-deazapurines (pyrrolo[2,3-d]pyrimidines) with N-imidyl peroxyesters. The reactions occur regioselectively at position 8 in 7-deazapurines, leading to a series of 8-succinimido-, phtalimido-, or naphthalimido-7-deazapurine derivatives. Attempted hydrazinolysis of resulting 8-imidyl-7-deazapurines led to corresponding 8-amino-7-deazapurine, which was very unstable and quickly decomposed.
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spelling pubmed-66416822019-08-27 C–H Imidation of 7-Deazapurines Sabat, Nazarii Poštová Slavětínská, Lenka Klepetářová, Blanka Hocek, Michal ACS Omega [Image: see text] We developed and presented here a ferrocene-catalyzed C–H imidation of 7-deazapurines (pyrrolo[2,3-d]pyrimidines) with N-imidyl peroxyesters. The reactions occur regioselectively at position 8 in 7-deazapurines, leading to a series of 8-succinimido-, phtalimido-, or naphthalimido-7-deazapurine derivatives. Attempted hydrazinolysis of resulting 8-imidyl-7-deazapurines led to corresponding 8-amino-7-deazapurine, which was very unstable and quickly decomposed. American Chemical Society 2018-04-27 /pmc/articles/PMC6641682/ /pubmed/31458688 http://dx.doi.org/10.1021/acsomega.8b00520 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sabat, Nazarii
Poštová Slavětínská, Lenka
Klepetářová, Blanka
Hocek, Michal
C–H Imidation of 7-Deazapurines
title C–H Imidation of 7-Deazapurines
title_full C–H Imidation of 7-Deazapurines
title_fullStr C–H Imidation of 7-Deazapurines
title_full_unstemmed C–H Imidation of 7-Deazapurines
title_short C–H Imidation of 7-Deazapurines
title_sort c–h imidation of 7-deazapurines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641682/
https://www.ncbi.nlm.nih.gov/pubmed/31458688
http://dx.doi.org/10.1021/acsomega.8b00520
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