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Asymptomatic left posterior mediastinal functional paraganglioma: A case report

RATIONALE: Paraganglioma refers to a set of neuroendocrine tumors derived from the chromaffin cells of the adrenal diplomatic ganglion. Paragangliomas can be classified as functional or nonfunctional based on the ability to synthesize and release catecholamines. PATIENT CONCERNS: We report a 47-year...

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Autores principales: Yue, Yang, Xin, Hua, Li, Fu-Qiang, Wu, Jun-Duo, Liu, Jun-Zhi, Zhang, Le-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641711/
https://www.ncbi.nlm.nih.gov/pubmed/31305440
http://dx.doi.org/10.1097/MD.0000000000016383
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author Yue, Yang
Xin, Hua
Li, Fu-Qiang
Wu, Jun-Duo
Liu, Jun-Zhi
Zhang, Le-Ning
author_facet Yue, Yang
Xin, Hua
Li, Fu-Qiang
Wu, Jun-Duo
Liu, Jun-Zhi
Zhang, Le-Ning
author_sort Yue, Yang
collection PubMed
description RATIONALE: Paraganglioma refers to a set of neuroendocrine tumors derived from the chromaffin cells of the adrenal diplomatic ganglion. Paragangliomas can be classified as functional or nonfunctional based on the ability to synthesize and release catecholamines. PATIENT CONCERNS: We report a 47-year-old man with a functional paraganglioma in the left posterior mediastinum and highlight the key elements of management of mediastinal paragangliomas. DIAGNOSES: A left posterior mediastinal mass was found by computed tomography (CT) scan and Chest-enhanced CT. Preoperative ultrasound-guided biopsy suggested the possibility of a paraganglioma. A diagnosis of paraganglioma was established by immunohistochemistry. INTERVENTIONS: The patient underwent single-stage resection of the lesion via left thoracotomy after preoperative oral α-adrenoceptor (phenoxybenzamine) therapy and intravenous fluid resuscitation for two weeks. OUTCOMES: The postoperative period was uneventful. The patient exhibited no abnormal blood pressure or recurrence during the 12-month follow-up period. LESSONS SUBSECTIONS AS PER STYLE: Pathological examination alone cannot determine whether it was a benign or malignant paraganglioma, which can be determined by pathological examination combined with distant metastasis. Long-term follow-up is required to assess the treatment effect.
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spelling pubmed-66417112019-08-15 Asymptomatic left posterior mediastinal functional paraganglioma: A case report Yue, Yang Xin, Hua Li, Fu-Qiang Wu, Jun-Duo Liu, Jun-Zhi Zhang, Le-Ning Medicine (Baltimore) Research Article RATIONALE: Paraganglioma refers to a set of neuroendocrine tumors derived from the chromaffin cells of the adrenal diplomatic ganglion. Paragangliomas can be classified as functional or nonfunctional based on the ability to synthesize and release catecholamines. PATIENT CONCERNS: We report a 47-year-old man with a functional paraganglioma in the left posterior mediastinum and highlight the key elements of management of mediastinal paragangliomas. DIAGNOSES: A left posterior mediastinal mass was found by computed tomography (CT) scan and Chest-enhanced CT. Preoperative ultrasound-guided biopsy suggested the possibility of a paraganglioma. A diagnosis of paraganglioma was established by immunohistochemistry. INTERVENTIONS: The patient underwent single-stage resection of the lesion via left thoracotomy after preoperative oral α-adrenoceptor (phenoxybenzamine) therapy and intravenous fluid resuscitation for two weeks. OUTCOMES: The postoperative period was uneventful. The patient exhibited no abnormal blood pressure or recurrence during the 12-month follow-up period. LESSONS SUBSECTIONS AS PER STYLE: Pathological examination alone cannot determine whether it was a benign or malignant paraganglioma, which can be determined by pathological examination combined with distant metastasis. Long-term follow-up is required to assess the treatment effect. Wolters Kluwer Health 2019-07-12 /pmc/articles/PMC6641711/ /pubmed/31305440 http://dx.doi.org/10.1097/MD.0000000000016383 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Yue, Yang
Xin, Hua
Li, Fu-Qiang
Wu, Jun-Duo
Liu, Jun-Zhi
Zhang, Le-Ning
Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title_full Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title_fullStr Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title_full_unstemmed Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title_short Asymptomatic left posterior mediastinal functional paraganglioma: A case report
title_sort asymptomatic left posterior mediastinal functional paraganglioma: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641711/
https://www.ncbi.nlm.nih.gov/pubmed/31305440
http://dx.doi.org/10.1097/MD.0000000000016383
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