Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines

[Image: see text] A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent...

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Autores principales: Reddy, N. Naresh Kumar, Nageswara Rao, Sadu, Ravi, Chitrakar, Adimurthy, Subbarayappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641739/
https://www.ncbi.nlm.nih.gov/pubmed/31457795
http://dx.doi.org/10.1021/acsomega.7b00969
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author Reddy, N. Naresh Kumar
Nageswara Rao, Sadu
Ravi, Chitrakar
Adimurthy, Subbarayappa
author_facet Reddy, N. Naresh Kumar
Nageswara Rao, Sadu
Ravi, Chitrakar
Adimurthy, Subbarayappa
author_sort Reddy, N. Naresh Kumar
collection PubMed
description [Image: see text] A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields.
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spelling pubmed-66417392019-08-27 Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines Reddy, N. Naresh Kumar Nageswara Rao, Sadu Ravi, Chitrakar Adimurthy, Subbarayappa ACS Omega [Image: see text] A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields. American Chemical Society 2017-08-30 /pmc/articles/PMC6641739/ /pubmed/31457795 http://dx.doi.org/10.1021/acsomega.7b00969 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Reddy, N. Naresh Kumar
Nageswara Rao, Sadu
Ravi, Chitrakar
Adimurthy, Subbarayappa
Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title_full Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title_fullStr Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title_full_unstemmed Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title_short Catalyst-Free Synthesis of 2,4-Disubstituted-1H-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines
title_sort catalyst-free synthesis of 2,4-disubstituted-1h-imidazoles through [3 + 2] cyclization of vinyl azides with amidines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641739/
https://www.ncbi.nlm.nih.gov/pubmed/31457795
http://dx.doi.org/10.1021/acsomega.7b00969
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