Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones

[Image: see text] We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH(Ph)(2) groups at the 2,6-...

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Autores principales: Ma, Xiaochen, Zuo, Ziqing, Liu, Guixia, Huang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641774/
https://www.ncbi.nlm.nih.gov/pubmed/31457754
http://dx.doi.org/10.1021/acsomega.7b00713
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author Ma, Xiaochen
Zuo, Ziqing
Liu, Guixia
Huang, Zheng
author_facet Ma, Xiaochen
Zuo, Ziqing
Liu, Guixia
Huang, Zheng
author_sort Ma, Xiaochen
collection PubMed
description [Image: see text] We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH(Ph)(2) groups at the 2,6-ortho positions of the imino aryl ring and a tBu group on the oxazoline ring furnishes the secondary alcohols in high enantioselectivities and yields.
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spelling pubmed-66417742019-08-27 Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones Ma, Xiaochen Zuo, Ziqing Liu, Guixia Huang, Zheng ACS Omega [Image: see text] We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH(Ph)(2) groups at the 2,6-ortho positions of the imino aryl ring and a tBu group on the oxazoline ring furnishes the secondary alcohols in high enantioselectivities and yields. American Chemical Society 2017-08-18 /pmc/articles/PMC6641774/ /pubmed/31457754 http://dx.doi.org/10.1021/acsomega.7b00713 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ma, Xiaochen
Zuo, Ziqing
Liu, Guixia
Huang, Zheng
Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title_full Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title_fullStr Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title_full_unstemmed Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title_short Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones
title_sort manganese-catalyzed asymmetric hydrosilylation of aryl ketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641774/
https://www.ncbi.nlm.nih.gov/pubmed/31457754
http://dx.doi.org/10.1021/acsomega.7b00713
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AT zuoziqing manganesecatalyzedasymmetrichydrosilylationofarylketones
AT liuguixia manganesecatalyzedasymmetrichydrosilylationofarylketones
AT huangzheng manganesecatalyzedasymmetrichydrosilylationofarylketones

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