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Lupus intestinal pseudo-obstruction and hydronephrosis: Case report

INTRODUCTION: Intestinal pseudo-obstruction (IPO) is a rare and life-threatening complication of lupus. PATIENT CONCERNS: A patient with long-standing lupus developed recurrent abdominal pain and distension as well as nausea and emesis. DIAGNOSIS: Imaging showed dilated small bowel loops with air-fl...

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Autores principales: Adler, Brittany L., Timlin, Homa, Birnbaum, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641825/
https://www.ncbi.nlm.nih.gov/pubmed/31305400
http://dx.doi.org/10.1097/MD.0000000000016178
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author Adler, Brittany L.
Timlin, Homa
Birnbaum, Julius
author_facet Adler, Brittany L.
Timlin, Homa
Birnbaum, Julius
author_sort Adler, Brittany L.
collection PubMed
description INTRODUCTION: Intestinal pseudo-obstruction (IPO) is a rare and life-threatening complication of lupus. PATIENT CONCERNS: A patient with long-standing lupus developed recurrent abdominal pain and distension as well as nausea and emesis. DIAGNOSIS: Imaging showed dilated small bowel loops with air-fluid levels and bowel wall thickening. She also had bilateral hydronephrosis. INTERVENTIONS: : She was given high-doses of intravenous steroids and cyclophosphamide. OUTCOMES: Her symptoms resolved within a week of starting immunosuppression. She was eventually transitioned to mycophenolate mofetil. She remained in remission and immunosuppression was successfully stopped after 1 year. CONCLUSIONS: Intestinal pseudo-obstruction is a rare complication of lupus that is often seen in association with ureterohydronephrosis and interstitial cystitis. This clinical syndrome is thought to be because of smooth muscle dysmotility of the gastrointestinal and genitourinary tracts, although the exact mechanism of dysmotility remains unknown. This condition is often responsive to immunosuppression if recognized and treated promptly.
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spelling pubmed-66418252019-08-15 Lupus intestinal pseudo-obstruction and hydronephrosis: Case report Adler, Brittany L. Timlin, Homa Birnbaum, Julius Medicine (Baltimore) Research Article INTRODUCTION: Intestinal pseudo-obstruction (IPO) is a rare and life-threatening complication of lupus. PATIENT CONCERNS: A patient with long-standing lupus developed recurrent abdominal pain and distension as well as nausea and emesis. DIAGNOSIS: Imaging showed dilated small bowel loops with air-fluid levels and bowel wall thickening. She also had bilateral hydronephrosis. INTERVENTIONS: : She was given high-doses of intravenous steroids and cyclophosphamide. OUTCOMES: Her symptoms resolved within a week of starting immunosuppression. She was eventually transitioned to mycophenolate mofetil. She remained in remission and immunosuppression was successfully stopped after 1 year. CONCLUSIONS: Intestinal pseudo-obstruction is a rare complication of lupus that is often seen in association with ureterohydronephrosis and interstitial cystitis. This clinical syndrome is thought to be because of smooth muscle dysmotility of the gastrointestinal and genitourinary tracts, although the exact mechanism of dysmotility remains unknown. This condition is often responsive to immunosuppression if recognized and treated promptly. Wolters Kluwer Health 2019-07-12 /pmc/articles/PMC6641825/ /pubmed/31305400 http://dx.doi.org/10.1097/MD.0000000000016178 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Adler, Brittany L.
Timlin, Homa
Birnbaum, Julius
Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title_full Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title_fullStr Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title_full_unstemmed Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title_short Lupus intestinal pseudo-obstruction and hydronephrosis: Case report
title_sort lupus intestinal pseudo-obstruction and hydronephrosis: case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641825/
https://www.ncbi.nlm.nih.gov/pubmed/31305400
http://dx.doi.org/10.1097/MD.0000000000016178
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