Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles

[Image: see text] A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale.

Detalles Bibliográficos
Autores principales: Singh, Anoop S., Mishra, Nidhi, Kumar, Dhananjay, Tiwari, Vinod K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641914/
https://www.ncbi.nlm.nih.gov/pubmed/31457781
http://dx.doi.org/10.1021/acsomega.7b00965
Descripción
Sumario:[Image: see text] A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale.

Ejemplares similares