Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles

[Image: see text] A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale.

Detalles Bibliográficos
Autores principales: Singh, Anoop S., Mishra, Nidhi, Kumar, Dhananjay, Tiwari, Vinod K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641914/
https://www.ncbi.nlm.nih.gov/pubmed/31457781
http://dx.doi.org/10.1021/acsomega.7b00965
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author Singh, Anoop S.
Mishra, Nidhi
Kumar, Dhananjay
Tiwari, Vinod K.
author_facet Singh, Anoop S.
Mishra, Nidhi
Kumar, Dhananjay
Tiwari, Vinod K.
author_sort Singh, Anoop S.
collection PubMed
description [Image: see text] A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale.
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spelling pubmed-66419142019-08-27 Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles Singh, Anoop S. Mishra, Nidhi Kumar, Dhananjay Tiwari, Vinod K. ACS Omega [Image: see text] A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale. American Chemical Society 2017-08-28 /pmc/articles/PMC6641914/ /pubmed/31457781 http://dx.doi.org/10.1021/acsomega.7b00965 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Singh, Anoop S.
Mishra, Nidhi
Kumar, Dhananjay
Tiwari, Vinod K.
Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title_full Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title_fullStr Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title_full_unstemmed Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title_short Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles
title_sort lewis-acid-mediated benzotriazole ring cleavage (btrc) strategy for the synthesis of 2-aryl benzoxazoles from n-acylbenzotriazoles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641914/
https://www.ncbi.nlm.nih.gov/pubmed/31457781
http://dx.doi.org/10.1021/acsomega.7b00965
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