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Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery

[Image: see text] Porous materials with molecular-scale ordering have attracted major attention mainly because of the possibility to engineer their pores for selective applications. Periodic mesoporous organosilica is a class of hybrid materials where self-assembly of the organic linkers provides a...

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Autores principales: Omar, Haneen, Moosa, Basem, Alamoudi, Kholod, Anjum, Dalaver H., Emwas, Abdul-Hamid, El Tall, Omar, Vu, Binh, Tamanoi, Fuyu, AlMalik, Abdulaziz, Khashab, Niveen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641955/
https://www.ncbi.nlm.nih.gov/pubmed/31458733
http://dx.doi.org/10.1021/acsomega.8b00418
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author Omar, Haneen
Moosa, Basem
Alamoudi, Kholod
Anjum, Dalaver H.
Emwas, Abdul-Hamid
El Tall, Omar
Vu, Binh
Tamanoi, Fuyu
AlMalik, Abdulaziz
Khashab, Niveen M.
author_facet Omar, Haneen
Moosa, Basem
Alamoudi, Kholod
Anjum, Dalaver H.
Emwas, Abdul-Hamid
El Tall, Omar
Vu, Binh
Tamanoi, Fuyu
AlMalik, Abdulaziz
Khashab, Niveen M.
author_sort Omar, Haneen
collection PubMed
description [Image: see text] Porous materials with molecular-scale ordering have attracted major attention mainly because of the possibility to engineer their pores for selective applications. Periodic mesoporous organosilica is a class of hybrid materials where self-assembly of the organic linkers provides a crystal-like pore wall. However, unlike metal coordination, specific geometries cannot be predicted because of the competitive and dynamic nature of noncovalent interactions. Herein, we study the influence of competing noncovalent interactions in the pore walls on the biodegradation of organosilica frameworks for drug delivery application. These results support the importance of studying self-assembly patterns in hybrid frameworks to better engineer the next generation of dynamic or “soft” porous materials.
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spelling pubmed-66419552019-08-27 Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery Omar, Haneen Moosa, Basem Alamoudi, Kholod Anjum, Dalaver H. Emwas, Abdul-Hamid El Tall, Omar Vu, Binh Tamanoi, Fuyu AlMalik, Abdulaziz Khashab, Niveen M. ACS Omega [Image: see text] Porous materials with molecular-scale ordering have attracted major attention mainly because of the possibility to engineer their pores for selective applications. Periodic mesoporous organosilica is a class of hybrid materials where self-assembly of the organic linkers provides a crystal-like pore wall. However, unlike metal coordination, specific geometries cannot be predicted because of the competitive and dynamic nature of noncovalent interactions. Herein, we study the influence of competing noncovalent interactions in the pore walls on the biodegradation of organosilica frameworks for drug delivery application. These results support the importance of studying self-assembly patterns in hybrid frameworks to better engineer the next generation of dynamic or “soft” porous materials. American Chemical Society 2018-05-14 /pmc/articles/PMC6641955/ /pubmed/31458733 http://dx.doi.org/10.1021/acsomega.8b00418 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Omar, Haneen
Moosa, Basem
Alamoudi, Kholod
Anjum, Dalaver H.
Emwas, Abdul-Hamid
El Tall, Omar
Vu, Binh
Tamanoi, Fuyu
AlMalik, Abdulaziz
Khashab, Niveen M.
Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title_full Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title_fullStr Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title_full_unstemmed Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title_short Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
title_sort impact of pore–walls ligand assembly on the biodegradation of mesoporous organosilica nanoparticles for controlled drug delivery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641955/
https://www.ncbi.nlm.nih.gov/pubmed/31458733
http://dx.doi.org/10.1021/acsomega.8b00418
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