Real-world evidence to guide healthcare policies in oncology

Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinica...

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Detalles Bibliográficos
Autores principales: Donia, Marco, Hansen, Steen Werner, Svane, Inge Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642046/
https://www.ncbi.nlm.nih.gov/pubmed/31360300
http://dx.doi.org/10.18632/oncotarget.27077
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author Donia, Marco
Hansen, Steen Werner
Svane, Inge Marie
author_facet Donia, Marco
Hansen, Steen Werner
Svane, Inge Marie
author_sort Donia, Marco
collection PubMed
description Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.
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spelling pubmed-66420462019-07-29 Real-world evidence to guide healthcare policies in oncology Donia, Marco Hansen, Steen Werner Svane, Inge Marie Oncotarget Research Perspective Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials. Impact Journals LLC 2019-07-16 /pmc/articles/PMC6642046/ /pubmed/31360300 http://dx.doi.org/10.18632/oncotarget.27077 Text en Copyright: © 2019 Donia et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Donia, Marco
Hansen, Steen Werner
Svane, Inge Marie
Real-world evidence to guide healthcare policies in oncology
title Real-world evidence to guide healthcare policies in oncology
title_full Real-world evidence to guide healthcare policies in oncology
title_fullStr Real-world evidence to guide healthcare policies in oncology
title_full_unstemmed Real-world evidence to guide healthcare policies in oncology
title_short Real-world evidence to guide healthcare policies in oncology
title_sort real-world evidence to guide healthcare policies in oncology
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642046/
https://www.ncbi.nlm.nih.gov/pubmed/31360300
http://dx.doi.org/10.18632/oncotarget.27077
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