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Placental effects and transfer of sildenafil in healthy and preeclamptic conditions

BACKGROUND: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity. METHODS: Ex vivo dual-sided perfusion of an isolated cotyledon and wire-...

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Detalles Bibliográficos
Autores principales:	Hitzerd, Emilie, Broekhuizen, Michelle, Mirabito Colafella, Katrina M., Glisic, Marija, de Vries, René, Koch, Birgit C.P., de Raaf, Michiel A., Merkus, Daphne, Schoenmakers, Sam, Reiss, Irwin K.M., Danser, A.H. Jan, Simons, Sinno H.P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642075/ https://www.ncbi.nlm.nih.gov/pubmed/31204276 http://dx.doi.org/10.1016/j.ebiom.2019.06.007

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