NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing. Here, we demonstrate that NQO1-targeting prodrug...

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Detalles Bibliográficos
Autores principales: Li, Xiaoguang, Liu, Zhida, Zhang, Anli, Han, Chuanhui, Shen, Aijun, Jiang, Lingxiang, Boothman, David A., Qiao, Jian, Wang, Yang, Huang, Xiumei, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642086/
https://www.ncbi.nlm.nih.gov/pubmed/31324798
http://dx.doi.org/10.1038/s41467-019-11238-1

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