Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence...

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Detalles Bibliográficos
Autores principales: Motta, Jean-Paul, Denadai-Souza, Alexandre, Sagnat, David, Guiraud, Laura, Edir, Anissa, Bonnart, Chrystelle, Sebbag, Mireille, Rousset, Perrine, Lapeyre, Ariane, Seguy, Carine, Mathurine-Thomas, Noa, Galipeau, Heather J., Bonnet, Delphine, Alric, Laurent, Buret, Andre G., Wallace, John L., Dufour, Antoine, Verdu, Elena F., Hollenberg, Morley D., Oswald, Eric, Serino, Matteo, Deraison, Celine, Vergnolle, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642099/
https://www.ncbi.nlm.nih.gov/pubmed/31324782
http://dx.doi.org/10.1038/s41467-019-11140-w

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