Genetic mapping of cell type specificity for complex traits

Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific transcriptome profiles. Such profiles can be aligned with genome-wide association studies (GWASs) to implicate cell type specificity of the traits. Current methods typically rely only on a small subset of available scRNA...

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Detalles Bibliográficos
Autores principales: Watanabe, Kyoko, Umićević Mirkov, Maša, de Leeuw, Christiaan A., van den Heuvel, Martijn P., Posthuma, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642112/
https://www.ncbi.nlm.nih.gov/pubmed/31324783
http://dx.doi.org/10.1038/s41467-019-11181-1

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