Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction

Hepatitis B virus (HBV) X protein, HBx, interacts with anti-apoptotic Bcl-2 and Bcl-xL proteins through its BH3-like motif to promote HBV replication and cytotoxicity. Here we report the crystal structure of HBx BH3-like motif in complex with Bcl-xL where the BH3-like motif adopts a short α-helix to...

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Detalles Bibliográficos
Autores principales: Zhang, Tian-Ying, Chen, Hong-Ying, Cao, Jia-Li, Xiong, Hua-Long, Mo, Xiao-Bing, Li, Tian-Liang, Kang, Xiao-Zhen, Zhao, Jing-Hua, Yin, Bo, Zhao, Xiang, Huang, Cheng-Hao, Yuan, Quan, Xue, Ding, Xia, Ning-Shao, Yuan, Y. Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642116/
https://www.ncbi.nlm.nih.gov/pubmed/31324803
http://dx.doi.org/10.1038/s41467-019-11173-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642116/
https://www.ncbi.nlm.nih.gov/pubmed/31324803
http://dx.doi.org/10.1038/s41467-019-11173-1

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