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Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis

Most antineoplastic chemotherapies eliminate cancer cells through activation of the mitochondria-controlled intrinsic apoptotic pathway. Therein, BAX, BAK, and/or BOK function as the essential pore-forming executioners of mitochondrial outer membrane permeabilization (MOMP). The activation threshold...

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Detalles Bibliográficos
Autores principales:	Heimer, Sina, Knoll, Gertrud, Schulze-Osthoff, Klaus, Ehrenschwender, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642130/ https://www.ncbi.nlm.nih.gov/pubmed/31324752 http://dx.doi.org/10.1038/s41419-019-1790-z

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