Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2

Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet dogs. To define the genomic underpinnings of canine OS, we performed multi-platform analysis of OS tumors from 59 dogs, including whole genome sequencing (n = 24) and whole exome sequencing (WES; n = 13) of prim...

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Detalles Bibliográficos
Autores principales: Gardner, Heather L., Sivaprakasam, Karthigayini, Briones, Natalia, Zismann, Victoria, Perdigones, Nieves, Drenner, Kevin, Facista, Salvatore, Richholt, Ryan, Liang, Winnie, Aldrich, Jessica, Trent, Jeffrey M., Shields, Peter G., Robinson, Nicholas, Johnson, Jeremy, Lana, Susan, Houghton, Peter, Fenger, Joelle, Lorch, Gwendolen, Janeway, Katherine A., London, Cheryl A., Hendricks, William P. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642146/
https://www.ncbi.nlm.nih.gov/pubmed/31341965
http://dx.doi.org/10.1038/s42003-019-0487-2

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