Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class antibody development has been limited by the rare nature of these responses during natural infection and the lack of lon...

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Detalles Bibliográficos
Autores principales: Umotoy, Jeffrey, Bagaya, Bernard S., Joyce, Collin, Schiffner, Torben, Menis, Sergey, Saye-Francisco, Karen L., Biddle, Trevor, Mohan, Sanjay, Vollbrecht, Thomas, Kalyuzhniy, Oleksander, Madzorera, Sharon, Kitchin, Dale, Lambson, Bronwen, Nonyane, Molati, Kilembe, William, Poignard, Pascal, Schief, William R., Burton, Dennis R., Murrell, Ben, Moore, Penny L., Briney, Bryan, Sok, Devin, Landais, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642152/
https://www.ncbi.nlm.nih.gov/pubmed/31315032
http://dx.doi.org/10.1016/j.immuni.2019.06.004

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