Cargando…

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bachmann, Nadine, von Siebenthal, Chantal, Vongrad, Valentina, Turk, Teja, Neumann, Kathrin, Beerenwinkel, Niko, Bogojeska, Jasmina, Fellay, Jaques, Roth, Volker, Kok, Yik Lim, Thorball, Christian W., Borghesi, Alessandro, Parbhoo, Sonali, Wieser, Mario, Böni, Jürg, Perreau, Matthieu, Klimkait, Thomas, Yerly, Sabine, Battegay, Manuel, Rauch, Andri, Hoffmann, Matthias, Bernasconi, Enos, Cavassini, Matthias, Kouyos, Roger D., Günthard, Huldrych F., Metzner, Karin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642170/ https://www.ncbi.nlm.nih.gov/pubmed/31324762 http://dx.doi.org/10.1038/s41467-019-10884-9

Ejemplares similares

A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits
por: Nadeau, Sarah, et al.
Publicado: (2022)

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
por: Wan, Chenjie, et al.
Publicado: (2020)

Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study
por: Kusejko, Katharina, et al.
Publicado: (2018)

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link
por: Nguyen, Huyen, et al.
Publicado: (2021)

Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis
por: Turk, Teja, et al.
Publicado: (2017)

The Cumulative Impact of Harm Reduction on the Swiss HIV Epidemic: Cohort Study, Mathematical Model, and Phylogenetic Analysis
por: Marzel, Alex, et al.
Publicado: (2018)

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity
por: Bertels, Frederic, et al.
Publicado: (2018)

The Individualized Genetic Barrier Predicts Treatment Response in a Large Cohort of HIV-1 Infected Patients
por: Beerenwinkel, Niko, et al.
Publicado: (2013)

Cohort-Derived Machine Learning Models for Individual Prediction of Chronic Kidney Disease in People Living With Human Immunodeficiency Virus: A Prospective Multicenter Cohort Study
por: Roth, Jan A, et al.
Publicado: (2020)

Ambiguous Nucleotide Calls From Population-based Sequencing of HIV-1 are a Marker for Viral Diversity and the Age of Infection
por: Kouyos, Roger D., et al.
Publicado: (2011)

HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection
por: Carlisle, Louisa A., et al.
Publicado: (2020)

Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells
por: Kok, Yik Lim, et al.
Publicado: (2016)

Correction: Long-Lasting Protection of Activity of Nucleoside Reverse Transcriptase Inhibitors and Protease Inhibitors (PIs) by Boosted PI Containing Regimens
por: Scherrer, Alexandra U., et al.
Publicado: (2013)

Long-Lasting Protection of Activity of Nucleoside Reverse Transcriptase Inhibitors and Protease Inhibitors (PIs) by Boosted PI Containing Regimens
por: Scherrer, Alexandra U., et al.
Publicado: (2012)

Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland
por: Shilaih, Mohaned, et al.
Publicado: (2016)

Predictors of Virological Failure and Time to Viral Suppression of First-Line Integrase Inhibitor–Based Antiretroviral Treatment
por: Pyngottu, Ashima, et al.
Publicado: (2020)

Adherence as a Predictor of the Development of Class-Specific Resistance Mutations: The Swiss HIV Cohort Study
por: von Wyl, Viktor, et al.
Publicado: (2013)

Phylogenetic Approach Reveals That Virus Genotype Largely Determines HIV Set-Point Viral Load
por: Alizon, Samuel, et al.
Publicado: (2010)

Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity
por: Kadelka, Claus, et al.
Publicado: (2018)

Minor Protease Inhibitor Mutations at Baseline Do Not Increase the Risk for a Virological Failure in HIV-1 Subtype B Infected Patients
por: Scherrer, Alexandra U., et al.
Publicado: (2012)

Disentangling Human Tolerance and Resistance Against HIV
por: Regoes, Roland R., et al.
Publicado: (2014)

Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics
por: Kusejko, Katharina, et al.
Publicado: (2022)

Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era
por: Salazar-Vizcaya, Luisa, et al.
Publicado: (2019)

Adverse events of raltegravir and dolutegravir
por: Elzi, Luigia, et al.
Publicado: (2017)

Inferring Epidemic Contact Structure from Phylogenetic Trees
por: Leventhal, Gabriel E., et al.
Publicado: (2012)

HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages
por: Vongrad, Valentina, et al.
Publicado: (2015)

Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study
por: Fehr, Jan, et al.
Publicado: (2011)

Assessing the drivers of syphilis among men who have sex with men in Switzerland reveals a key impact of screening frequency: A modelling study
por: Balakrishna, Suraj, et al.
Publicado: (2021)

Detecting Selection in the HIV-1 Genome during Sexual Transmission Events
por: Seifert, David, et al.
Publicado: (2022)

Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector
por: Kok, Yik Lim, et al.
Publicado: (2018)

CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART
por: Sauter, Rafael, et al.
Publicado: (2016)

Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics
por: Kühnert, Denise, et al.
Publicado: (2018)

Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup
por: Bachmann, Nadine, et al.
Publicado: (2017)

Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study
por: Young, Jim, et al.
Publicado: (2015)

Increases in Condomless Sex in the Swiss HIV Cohort Study
por: Kouyos, Roger D., et al.
Publicado: (2015)

Early Antiretroviral Therapy During Primary HIV-1 Infection Results in a Transient Reduction of the Viral Setpoint upon Treatment Interruption
por: von Wyl, Viktor, et al.
Publicado: (2011)

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma
por: Thorball, Christian W., et al.
Publicado: (2020)

Persistence of Transmitted HIV-1 Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds
por: Yang, Wan-Lin, et al.
Publicado: (2015)

Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population
por: Gueler, Aysel, et al.
Publicado: (2017)

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data
por: Beerenwinkel, Niko, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pqo5vthk8tea0lh6cuni6sf3gl