Two types of functionally distinct Ca(2+) stores in hippocampal neurons

It is widely assumed that inositol trisphosphate (IP(3)) and ryanodine (Ry) receptors share the same Ca(2+) pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP(3)- and Ry-receptors are associated with two functionally distinct intracellular Ca(2+) store...

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Autores principales: Chen-Engerer, Hsing-Jung, Hartmann, Jana, Karl, Rosa Maria, Yang, Jun, Feske, Stefan, Konnerth, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642203/
https://www.ncbi.nlm.nih.gov/pubmed/31324793
http://dx.doi.org/10.1038/s41467-019-11207-8
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author Chen-Engerer, Hsing-Jung
Hartmann, Jana
Karl, Rosa Maria
Yang, Jun
Feske, Stefan
Konnerth, Arthur
author_facet Chen-Engerer, Hsing-Jung
Hartmann, Jana
Karl, Rosa Maria
Yang, Jun
Feske, Stefan
Konnerth, Arthur
author_sort Chen-Engerer, Hsing-Jung
collection PubMed
description It is widely assumed that inositol trisphosphate (IP(3)) and ryanodine (Ry) receptors share the same Ca(2+) pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP(3)- and Ry-receptors are associated with two functionally distinct intracellular Ca(2+) stores, respectively. While the IP(3)-sensitive Ca(2+) store refilling requires Orai2 channels, Ry-sensitive Ca(2+) store refilling involves voltage-gated Ca(2+) channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.
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spelling pubmed-66422032019-07-22 Two types of functionally distinct Ca(2+) stores in hippocampal neurons Chen-Engerer, Hsing-Jung Hartmann, Jana Karl, Rosa Maria Yang, Jun Feske, Stefan Konnerth, Arthur Nat Commun Article It is widely assumed that inositol trisphosphate (IP(3)) and ryanodine (Ry) receptors share the same Ca(2+) pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP(3)- and Ry-receptors are associated with two functionally distinct intracellular Ca(2+) stores, respectively. While the IP(3)-sensitive Ca(2+) store refilling requires Orai2 channels, Ry-sensitive Ca(2+) store refilling involves voltage-gated Ca(2+) channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons. Nature Publishing Group UK 2019-07-19 /pmc/articles/PMC6642203/ /pubmed/31324793 http://dx.doi.org/10.1038/s41467-019-11207-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen-Engerer, Hsing-Jung
Hartmann, Jana
Karl, Rosa Maria
Yang, Jun
Feske, Stefan
Konnerth, Arthur
Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title_full Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title_fullStr Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title_full_unstemmed Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title_short Two types of functionally distinct Ca(2+) stores in hippocampal neurons
title_sort two types of functionally distinct ca(2+) stores in hippocampal neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642203/
https://www.ncbi.nlm.nih.gov/pubmed/31324793
http://dx.doi.org/10.1038/s41467-019-11207-8
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