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Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine

The bromodomain and extra terminal domain (BET) family members, including BRD2, BRD3, and BRD4, act as epigenetic readers to regulate gene expression. Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that participates in tumor immune escape primarily by catalyzing tryptophan to l-kynurenine. Here,...

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Detalles Bibliográficos
Autores principales:	Tian, Chang-Qing, Chen, Lin, Chen, Hua-Dong, Huan, Xia-Juan, Hu, Jian-Ping, Shen, Jing-Kang, Xiong, Bing, Wang, Ying-Qing, Miao, Ze-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642217/ https://www.ncbi.nlm.nih.gov/pubmed/31324754 http://dx.doi.org/10.1038/s41419-019-1793-9

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