Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine

Dopamine transporter (SLC6A3) deficiency causes infantile Parkinson disease, for which there is no effective therapy. We have explored the effects of genetically deleting SLC6A3 in zebrafish. Unlike the wild-type, slc6a3−/− fish hover near the tank bottom, with a repetitive digging-like behavior. sl...

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Detalles Bibliográficos
Autores principales: Wang, Guangliang, Zhang, Guoqiang, Li, Zhuyun, Fawcett, Caroline H., Coble, Matthew, Sosa, Maria X., Tsai, Tingwei, Malesky, Kimberly, Thibodeaux, Stefan J., Zhu, Peixin, Glass, David J., Fishman, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642228/
https://www.ncbi.nlm.nih.gov/pubmed/31325771
http://dx.doi.org/10.1016/j.isci.2019.06.039

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