Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children

BACKGROUND: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. METHODS: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome profiling was performed in Kenyan children (n = 144, 3–36 months) with disc...

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Detalles Bibliográficos
Autores principales: Achieng, Angela O., Hengartner, Nicolas W., Raballah, Evans, Cheng, Qiuying, Anyona, Samuel B., Lauve, Nick, Guyah, Bernard, Foo-Hurwitz, Ivy, Ong'echa, John M., McMahon, Benjamin H., Ouma, Collins, Lambert, Christophe G., Perkins, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642287/
https://www.ncbi.nlm.nih.gov/pubmed/31278068
http://dx.doi.org/10.1016/j.ebiom.2019.06.043

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