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Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population

Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various disea...

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Autores principales: Huang, Wendong, Zhou, Huazhong, Pi, Lei, Xu, Yufen, Fu, LanYan, Yang, Yanfang, Che, Di, Gu, Xiaoqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642304/
https://www.ncbi.nlm.nih.gov/pubmed/31124188
http://dx.doi.org/10.1002/jcla.22919
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author Huang, Wendong
Zhou, Huazhong
Pi, Lei
Xu, Yufen
Fu, LanYan
Yang, Yanfang
Che, Di
Gu, Xiaoqiong
author_facet Huang, Wendong
Zhou, Huazhong
Pi, Lei
Xu, Yufen
Fu, LanYan
Yang, Yanfang
Che, Di
Gu, Xiaoqiong
author_sort Huang, Wendong
collection PubMed
description Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647‐1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475‐1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653‐1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505‐1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions.
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spelling pubmed-66423042019-11-12 Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population Huang, Wendong Zhou, Huazhong Pi, Lei Xu, Yufen Fu, LanYan Yang, Yanfang Che, Di Gu, Xiaoqiong J Clin Lab Anal Research Articles Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647‐1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475‐1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653‐1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505‐1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions. John Wiley and Sons Inc. 2019-05-23 /pmc/articles/PMC6642304/ /pubmed/31124188 http://dx.doi.org/10.1002/jcla.22919 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Huang, Wendong
Zhou, Huazhong
Pi, Lei
Xu, Yufen
Fu, LanYan
Yang, Yanfang
Che, Di
Gu, Xiaoqiong
Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title_full Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title_fullStr Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title_full_unstemmed Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title_short Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population
title_sort association between the rs2288947 polymorphism of the lncrna tincr gene and the risk of recurrent miscarriage in a southern chinese population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642304/
https://www.ncbi.nlm.nih.gov/pubmed/31124188
http://dx.doi.org/10.1002/jcla.22919
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