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Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial
BACKGROUND: This study assessed the effects of a lactobacillus-based medication on pain intensity scores in women with endometriosis. MATERIALS AND METHODS: The present randomized pilot placebo-controlled trial was done on eligible women who were surgically and pathologically diagnosed with endometr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642422/ https://www.ncbi.nlm.nih.gov/pubmed/31310070 http://dx.doi.org/10.22074/ijfs.2019.5584 |
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author | Khodaverdi, Sepideh Mohammadbeigi, Robabeh Khaledi, Mojdeh Mesdaghinia, Leila Sharifzadeh, Fatemeh Nasiripour, Somayyeh Gorginzadeh, Mansoureh |
author_facet | Khodaverdi, Sepideh Mohammadbeigi, Robabeh Khaledi, Mojdeh Mesdaghinia, Leila Sharifzadeh, Fatemeh Nasiripour, Somayyeh Gorginzadeh, Mansoureh |
author_sort | Khodaverdi, Sepideh |
collection | PubMed |
description | BACKGROUND: This study assessed the effects of a lactobacillus-based medication on pain intensity scores in women with endometriosis. MATERIALS AND METHODS: The present randomized pilot placebo-controlled trial was done on eligible women who were surgically and pathologically diagnosed with endometriosis. Thirty-seven participants who had not received hormonal treatment in the last three months, were enrolled and randomized into LactoFem(®)and placebo groups. Lactobacillus capsules or placebo were administrated orally once a day for 8 weeks. Patients were assessed for pain severity using Visual Analogue Scale (VAS) scores for dysmenorrhea, dyspareunia and chronic pelvic pain at baseline and after 8 and 12 weeks post-intervention. RESULTS: Mean age of participants and mean body mass index (BMI) for the LactoFem(®)and control groups were compara- ble. All patients had stage 3 and 4 of the disease based on revised American fertility society (AFS) classification of endome- triosis. Mean initial pain scores for dysmenorrhea, dyspareunia and chronic pelvic pain were 6.53 ± 2.88, 4.82 ± 3.76 and 4.19 ± 3.53, respectively in the LactoFem(®)group and 5.60 ± 2.06, 3.67 ± 2.64 and 2.88 ± 2.80, respectively for the control group; the two groups had comparable scores in this regard. There was more decrease in pain scores for both dysmenorrhea and the overall pain after 8 weeks of treatment in LactoFem(®)group compared to the control group. The scores for dysmen- orrhea were 6.53 ± 2.88 and 5.60 ± 2.06 in the LactoFem(®)and control groups, respectively, before intervention but, after 8-week treatment, these values were 3.07 ± 2.49 and 4.47 ± 2.13 (P=0.018), respectively. The changes in overall pain score in the LactoFem(®) and control group during this period were 7.33 ± 7.00 and 4.11 ± 1.68, respectively (P=0.017). CONCLUSION: This study showed some beneficial effects of lactobacillus administration on endometriosis-related pain (Registration number: IRCT20150819023684N5). |
format | Online Article Text |
id | pubmed-6642422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-66424222019-10-01 Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial Khodaverdi, Sepideh Mohammadbeigi, Robabeh Khaledi, Mojdeh Mesdaghinia, Leila Sharifzadeh, Fatemeh Nasiripour, Somayyeh Gorginzadeh, Mansoureh Int J Fertil Steril Original Article BACKGROUND: This study assessed the effects of a lactobacillus-based medication on pain intensity scores in women with endometriosis. MATERIALS AND METHODS: The present randomized pilot placebo-controlled trial was done on eligible women who were surgically and pathologically diagnosed with endometriosis. Thirty-seven participants who had not received hormonal treatment in the last three months, were enrolled and randomized into LactoFem(®)and placebo groups. Lactobacillus capsules or placebo were administrated orally once a day for 8 weeks. Patients were assessed for pain severity using Visual Analogue Scale (VAS) scores for dysmenorrhea, dyspareunia and chronic pelvic pain at baseline and after 8 and 12 weeks post-intervention. RESULTS: Mean age of participants and mean body mass index (BMI) for the LactoFem(®)and control groups were compara- ble. All patients had stage 3 and 4 of the disease based on revised American fertility society (AFS) classification of endome- triosis. Mean initial pain scores for dysmenorrhea, dyspareunia and chronic pelvic pain were 6.53 ± 2.88, 4.82 ± 3.76 and 4.19 ± 3.53, respectively in the LactoFem(®)group and 5.60 ± 2.06, 3.67 ± 2.64 and 2.88 ± 2.80, respectively for the control group; the two groups had comparable scores in this regard. There was more decrease in pain scores for both dysmenorrhea and the overall pain after 8 weeks of treatment in LactoFem(®)group compared to the control group. The scores for dysmen- orrhea were 6.53 ± 2.88 and 5.60 ± 2.06 in the LactoFem(®)and control groups, respectively, before intervention but, after 8-week treatment, these values were 3.07 ± 2.49 and 4.47 ± 2.13 (P=0.018), respectively. The changes in overall pain score in the LactoFem(®) and control group during this period were 7.33 ± 7.00 and 4.11 ± 1.68, respectively (P=0.017). CONCLUSION: This study showed some beneficial effects of lactobacillus administration on endometriosis-related pain (Registration number: IRCT20150819023684N5). Royan Institute 2019 2019-07-14 /pmc/articles/PMC6642422/ /pubmed/31310070 http://dx.doi.org/10.22074/ijfs.2019.5584 Text en The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khodaverdi, Sepideh Mohammadbeigi, Robabeh Khaledi, Mojdeh Mesdaghinia, Leila Sharifzadeh, Fatemeh Nasiripour, Somayyeh Gorginzadeh, Mansoureh Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial |
title | Beneficial Effects of Oral Lactobacillus on Pain Severity in Women
Suffering from Endometriosis: A Pilot Placebo-Controlled
Randomized Clinical Trial |
title_full | Beneficial Effects of Oral Lactobacillus on Pain Severity in Women
Suffering from Endometriosis: A Pilot Placebo-Controlled
Randomized Clinical Trial |
title_fullStr | Beneficial Effects of Oral Lactobacillus on Pain Severity in Women
Suffering from Endometriosis: A Pilot Placebo-Controlled
Randomized Clinical Trial |
title_full_unstemmed | Beneficial Effects of Oral Lactobacillus on Pain Severity in Women
Suffering from Endometriosis: A Pilot Placebo-Controlled
Randomized Clinical Trial |
title_short | Beneficial Effects of Oral Lactobacillus on Pain Severity in Women
Suffering from Endometriosis: A Pilot Placebo-Controlled
Randomized Clinical Trial |
title_sort | beneficial effects of oral lactobacillus on pain severity in women
suffering from endometriosis: a pilot placebo-controlled
randomized clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642422/ https://www.ncbi.nlm.nih.gov/pubmed/31310070 http://dx.doi.org/10.22074/ijfs.2019.5584 |
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