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Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion
BACKGROUND: Toxoplasma gondii is one of the major causes of abortion in pregnant women. Most cases of abortion occur in the acute phase of infection and early pregnancy. The purpose of this study was to investigate the association between spontaneous abortion and seropositive status of toxoplasmosis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642426/ https://www.ncbi.nlm.nih.gov/pubmed/31310071 http://dx.doi.org/10.22074/ijfs.2019.5740 |
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author | Kheirandish, Farnaz Ezatpour, Behrouz Fallahi, Shirzad Tarahi, Mohammad Javad Hosseini, Pardis Karimi Rouzbahani, Arian Seyyed Tabaei, Seyyed Javad Akbari, Soheila |
author_facet | Kheirandish, Farnaz Ezatpour, Behrouz Fallahi, Shirzad Tarahi, Mohammad Javad Hosseini, Pardis Karimi Rouzbahani, Arian Seyyed Tabaei, Seyyed Javad Akbari, Soheila |
author_sort | Kheirandish, Farnaz |
collection | PubMed |
description | BACKGROUND: Toxoplasma gondii is one of the major causes of abortion in pregnant women. Most cases of abortion occur in the acute phase of infection and early pregnancy. The purpose of this study was to investigate the association between spontaneous abortion and seropositive status of toxoplasmosis in women with first-time spontaneous abor- tion. MATERIALS AND METHODS: This research is a case-control study on 240 serum samples from women experiencing spon- taneous abortion for the first time as the case group, and 240 serum samples from women who had a normal delivery with no history of abortion as the control group. The level of anti-Toxoplasma gondii IgM and IgG antibodies were assessed in serum samples using ELISA. To separate the acute and chronic infections, all IgM-positive samples in both groups and IgG-positive samples of the case group were examined using IgG avidity. RESULTS: The Toxoplasma IgM antibody was detected in 3.3% (8/240) of the case group and 0.4% (1/240) of the con- trol group, which was a statistically significant difference between the two groups [P=0.019, odds ratio (OR)=10.266]. Of all samples 47.5% and 46.3% of the case and control groups were positive for Toxoplasma IgG antibody, respec- tively. Seven out of 8 (87.5%) IgM-positive serum samples from the case group had low IgG avidity, indicating acute infections, whereas all IgG-positive sera and 1 IgM-positive serum, which was related to the control group, showed a high IgG avidity, indicating chronic infections. CONCLUSION: Maternal acute toxoplasmosis during pregnancy is raised as one of the factors that increase the chance of spontaneous abortion. The necessary health training, especially on the parasite transmission ways to women before marriage, as well as the serological test in women before and during pregnancy is recommended. Polymerase chain reaction (PCR) and IgG avidity assays should be performed in the medical diagnostic laboratories for accurate distin- guishing of the initial infection of toxoplasmosis in the pregnant women. |
format | Online Article Text |
id | pubmed-6642426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-66424262019-10-01 Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion Kheirandish, Farnaz Ezatpour, Behrouz Fallahi, Shirzad Tarahi, Mohammad Javad Hosseini, Pardis Karimi Rouzbahani, Arian Seyyed Tabaei, Seyyed Javad Akbari, Soheila Int J Fertil Steril Original Article BACKGROUND: Toxoplasma gondii is one of the major causes of abortion in pregnant women. Most cases of abortion occur in the acute phase of infection and early pregnancy. The purpose of this study was to investigate the association between spontaneous abortion and seropositive status of toxoplasmosis in women with first-time spontaneous abor- tion. MATERIALS AND METHODS: This research is a case-control study on 240 serum samples from women experiencing spon- taneous abortion for the first time as the case group, and 240 serum samples from women who had a normal delivery with no history of abortion as the control group. The level of anti-Toxoplasma gondii IgM and IgG antibodies were assessed in serum samples using ELISA. To separate the acute and chronic infections, all IgM-positive samples in both groups and IgG-positive samples of the case group were examined using IgG avidity. RESULTS: The Toxoplasma IgM antibody was detected in 3.3% (8/240) of the case group and 0.4% (1/240) of the con- trol group, which was a statistically significant difference between the two groups [P=0.019, odds ratio (OR)=10.266]. Of all samples 47.5% and 46.3% of the case and control groups were positive for Toxoplasma IgG antibody, respec- tively. Seven out of 8 (87.5%) IgM-positive serum samples from the case group had low IgG avidity, indicating acute infections, whereas all IgG-positive sera and 1 IgM-positive serum, which was related to the control group, showed a high IgG avidity, indicating chronic infections. CONCLUSION: Maternal acute toxoplasmosis during pregnancy is raised as one of the factors that increase the chance of spontaneous abortion. The necessary health training, especially on the parasite transmission ways to women before marriage, as well as the serological test in women before and during pregnancy is recommended. Polymerase chain reaction (PCR) and IgG avidity assays should be performed in the medical diagnostic laboratories for accurate distin- guishing of the initial infection of toxoplasmosis in the pregnant women. Royan Institute 2019 2019-07-14 /pmc/articles/PMC6642426/ /pubmed/31310071 http://dx.doi.org/10.22074/ijfs.2019.5740 Text en The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kheirandish, Farnaz Ezatpour, Behrouz Fallahi, Shirzad Tarahi, Mohammad Javad Hosseini, Pardis Karimi Rouzbahani, Arian Seyyed Tabaei, Seyyed Javad Akbari, Soheila Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion |
title | Toxoplasma Serology Status and Risk of Miscarriage, A
Case-Control Study among Women with A History of
Spontaneous Abortion |
title_full | Toxoplasma Serology Status and Risk of Miscarriage, A
Case-Control Study among Women with A History of
Spontaneous Abortion |
title_fullStr | Toxoplasma Serology Status and Risk of Miscarriage, A
Case-Control Study among Women with A History of
Spontaneous Abortion |
title_full_unstemmed | Toxoplasma Serology Status and Risk of Miscarriage, A
Case-Control Study among Women with A History of
Spontaneous Abortion |
title_short | Toxoplasma Serology Status and Risk of Miscarriage, A
Case-Control Study among Women with A History of
Spontaneous Abortion |
title_sort | toxoplasma serology status and risk of miscarriage, a
case-control study among women with a history of
spontaneous abortion |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642426/ https://www.ncbi.nlm.nih.gov/pubmed/31310071 http://dx.doi.org/10.22074/ijfs.2019.5740 |
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