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Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, can reduce...

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Detalles Bibliográficos
Autores principales:	Li, Yan-Hua, Xu, Fang, Thome, Rodolfo, Guo, Min-Fang, Sun, Man-Luan, Song, Guo-Bin, Li, Rui-lan, Chai, Zhi, Ciric, Bogoljub, Rostami, A. M., Curtis, Mark, Ma, Cun-Gen, Zhang, Guang-Xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642537/ https://www.ncbi.nlm.nih.gov/pubmed/31324254 http://dx.doi.org/10.1186/s12974-019-1542-0

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