Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis

BACKGROUND: Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are active players in melanoma progression involved in the formation of the pre-met...

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Detalles Bibliográficos
Autores principales: Mannavola, Francesco, Tucci, Marco, Felici, Claudia, Passarelli, Anna, D’Oronzo, Stella, Silvestris, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642540/
https://www.ncbi.nlm.nih.gov/pubmed/31324252
http://dx.doi.org/10.1186/s12967-019-1982-4

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