HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality

BACKGROUND: Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune function...

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Detalles Bibliográficos
Autores principales: Richards, David M., Marschall, Viola, Billian-Frey, Katharina, Heinonen, Karl, Merz, Christian, Redondo Müller, Mauricio, Sefrin, Julian P., Schröder, Matthias, Sykora, Jaromir, Fricke, Harald, Hill, Oliver, Gieffers, Christian, Thiemann, Meinolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642547/
https://www.ncbi.nlm.nih.gov/pubmed/31324216
http://dx.doi.org/10.1186/s40425-019-0671-4

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