Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

BACKGROUND: Innate immune cells such as macrophages are abundantly present within malignant ascites, where they share the microenvironment with ovarian cancer stem cells (CSC). METHODS: To mimic this malignant ascites microenvironment, we created a hanging-drop hetero-spheroid model to bring CSCs an...

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Detalles Bibliográficos
Autores principales: Raghavan, Shreya, Mehta, Pooja, Xie, Yuying, Lei, Yu L., Mehta, Geeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642605/
https://www.ncbi.nlm.nih.gov/pubmed/31324218
http://dx.doi.org/10.1186/s40425-019-0666-1

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